Association for the Advancement of Blood & Biotherapies Relationship Testing Statistical Calculation Training Module 2

Description

+ Include:  videos + file sub vtt +  pdf, size:  GB

+ Target Audience: Medical Geneticists, Forensic Pathologists, and Clinical Pathologists

+ Sample video: contact me for sample video

+ Information:

This unique online program offered by the Association for the Advancement of Blood & Biotherapies (AABB) seeks to educate laboratory scientists and forensic analysts on the statistical methods used to determine non-parentage familial relationships. The foundational course is designed as an independent, self-paced, multi-media training that takes approximately 6-8 hours to complete. It includes practice exercise worksheets, downloadable MP3 audio files, and a handout for each unit.

Learning Objectives

Upon successful completion of this course, learners should be able to:

• Discuss the derivation of the kinship index.

• Perform two-party calculations for siblings, half-siblings, avuncular, and single grandparentage.

• Write a statement of the estimation of uncertainty for two-party kinship calculations.

• Perform kinship calculations with three or more people.

Target Audience

The program is designed to educate laboratory scientists and forensic analysts. Learners should already have the foundational knowledge and ability to calculate basic parentage relationship statistics involving duos and trios. Best for Medical Geneticists, Forensic Pathologists, and Clinical Pathologists.

Topics

The course is divided into four distinct units, each building upon the prior one to establish a comprehensive understanding of non-parentage kinship calculations:

• Unit 1: Introduction to Kinship Analysis: Calculation of the Kinship Index for Full Sibling Pairs

  • Discuss the degrees of biological relationships and the principles used in DNA-based kinship testing.

  • Perform two-party calculations to evaluate alleged full sibling relationships.

• Unit 2: Second Degree Two Parties Kinship Testing: Half siblings, Aunt/Uncle, Nephew/Niece and Grandparent and Grandchild. Reporting Results for Two Party Testing

  • Describe second degree relationships.

  • Perform two-party calculations for half siblings, avuncular and single grandparent.

  • Write a statement of the estimation of uncertainty for two-party calculations when reporting results.

• Unit 3: Grandparentage with Two Grandparents and Grandchild with and without the Mother

  • Reconstruct a missing parent’s genotype using his or her parents.

  • Perform Grandparentage calculations using both grandparents.

  • Discuss the advantages and disadvantages of Grandparentage testing.

• Unit 4: Testing with More than Two People in Sibling Relationships (Full and Half Siblings)

  • Describe testing with an acknowledged (undisputed) parent when a sibling relationship is questioned.

  • Perform calculations to determine full and half sibling relationships with three or more parties.